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ALFRED LEE EDGAR / CO-AUTHORED WORK

Published Research.

A body of inquiry, open for anyone to examine. Explore Lee’s published papers on physiology, cancer metabolism, and the living interfaces that shape biological response.

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01 / THE PUBLICATIONS2024—2026

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These papers list Lee Edgar (also indexed as Alfred Lee Edgar) among their authors. Each entry links to its PubMed record, where you can read the abstract, full author list, and available full text.

The papers include reviews and conceptual frameworks. They investigate and propose ideas; they are not clinical trials demonstrating a treatment.

  1. 012026

    MEMBRANE SIGNALING / FRONTIERS IN PHYSIOLOGY

    Membrane-decisional architecture: a framework for multigenomic signal prioritization in the plasma membrane nanobiome

    A proposed framework for how membrane organization could influence which signals a cell receives, prioritizes, and routes. The authors present it as a hypothesis-derived model for future testing.

    Gaspary JFP et al. Front Physiol. 2026;17:1828577. DOI: 10.3389/fphys.2026.1828577.

    Read the PubMed record
  2. 022026

    HOST–MICROBIOME SYSTEMS / FRONTIERS IN MICROBIOLOGY

    Mapping the multigenomic human system: structural asymmetry and interface gaps in host–exogenous biological interactions

    A structured synthesis of research on host–microbe interactions, asking how microbial and environmental signals become part of human physiological regulation.

    Gaspary JFP et al. Front Microbiol. 2026;17:1834677. DOI: 10.3389/fmicb.2026.1834677.

    Read the PubMed record
  3. 032026

    ADAPTIVE PHYSIOLOGY / FRONTIERS IN MEDICINE

    Stabilized adaptive states in microbiome–human integrated physiology: reframing health and chronic disease as symbiotic biological states

    A systems-level review exploring how interactions among the microbiome, host tissues, and regulatory interfaces may help maintain physiological states over time.

    Gaspary JFP et al. Front Med (Lausanne). 2026;13:1824897. DOI: 10.3389/fmed.2026.1824897.

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  4. 042025

    ANCESTRAL PRACTICES / EXPLORE

    Translational reinterpretation of ancestral healing rituals: Structured physiological modulation through adaptive biological responses

    A review proposing ways to study ritual practices through redox biology, bioenergetics, and adaptive physiology, while identifying mechanisms that need experimental testing.

    Gaspary JFP et al. Explore (NY). 2025;21(6):103274. DOI: 10.1016/j.explore.2025.103274.

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  5. 052025

    CANCER METABOLISM / FRONTIERS IN ONCOLOGY

    Hydrated proton complexes supplementation for tumor microenvironment reprogramming: a bioenergetic strategy targeting the Warburg effect and mitochondrial dysfunction

    A systematic review examining a proposed hydrated-proton approach to the tumor microenvironment. Its therapeutic implications remain to be tested in preclinical and clinical studies.

    Edgar AL et al. Front Oncol. 2025;15:1647054. DOI: 10.3389/fonc.2025.1647054.

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  6. 062024

    CARBON DIOXIDE / FRONTIERS IN PHYSIOLOGY

    Translational insights into the hormetic potential of carbon dioxide: from physiological mechanisms to innovative adjunct therapeutic potential for cancer

    A translational review of carbon dioxide’s roles in oxygen delivery, pH regulation, and the tumor microenvironment, proposing directions for experimental validation.

    Gaspary JFP et al. Front Physiol. 2024;15:1415037. DOI: 10.3389/fphys.2024.1415037.

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Research moves forward by testing ideas, refining models, and allowing evidence to change the story. For a reader-friendly look at the physiology behind Inner Alchemy, explore the scientific overview.

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